Lion's Mane mushroom is generally considered safe for most people when consumed as a food or dietary supplement, however, as with any natural product or supplement, there are potential side effects and considerations to be aware of, such as:

• Allergic reactions
• Gastrointestinal discomfort (rare case)

Lion's Mane may interact with certain medications, especially those related to blood clotting, diabetes, or immunosuppressants. If you are taking any medications or have any underlying health conditions, it's crucial to discuss the use of Lion's Mane with your healthcare provider to avoid potential adverse effects or interactions.

Lion's Mane is known for its potential cognitive-enhancing and mood-stabilising effects, which have led to some studies exploring its use as a complementary therapy for conditions like depression and anxiety. However, interactions between supplements and antidepressant medications are possible, and individual responses can vary.

Some antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants, work by affecting neurotransmitter levels in the brain. Taking Lion's Mane alongside these medications could potentially influence serotonin levels and may lead to adverse effects or unexpected interactions.